Jena, September 25, 2026 – In light of the global rise in resistance to conventional medication, alternative treatment approaches are gaining importance. A research team in Jena, led by Mathias Pletz, is intensively focusing on the combination of phages and antibiotics.
- Topic: Innovative combatting of resistant bacteria through phage-antibiotic combinations
- Protagonist: Prof. Dr. Mathias Pletz (Jena)
- Focus: Supporting the mechanism of action of antibiotics using natural viruses
How Phages Support the Mechanism of Action
Phages are viruses that specifically infect and destroy bacteria without harming human cells. As part of current research in Jena, scientists are investigating how these natural bacterial enemies can be used in a targeted manner to break through the protective layers of resistant pathogens. If the phages succeed in weakening or attacking the pathogens, conventional antibiotics can once again reach their target site and exert their full effect. This synergistic principle opens up entirely new perspectives in infectiology.
Significance for the Future of Medicine
The work of Mathias Pletz and his team at the Friedrich-Schiller-Universität Jena is considered pioneering for the region and for clinical practice. As multi-resistant germs are among the greatest health challenges of our time, the standardized application of this drug combination could sustainably expand the therapeutic repertoire and save lives in the coming years.
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Background: Phage Therapy in Transition
So-called phage therapy was researched even before the discovery of penicillin, but later took a backseat in many Western countries in favor of antibiotics. Due to the global rise in antibiotic resistance, research into bacteriophages is experiencing a renaissance. Scientists worldwide – and increasingly in Jena – are driving development forward to create tailored therapies against stubborn germs.
Source:
Research from Thuringia – The Jena Mixture against resistant bacteria
Transparency note: This article was created automatically, editorially reviewed, and expanded with AI support.